First-in-mouse 解析

First-in-mouse 解析
First-in-mouse analysis

(担当:川田 学)
(Member in charge: Manabu Kawada)



タンパク質や細胞などを使用したin vitroの実験から発見、開発された化合物が、生体でどのような作用を発揮するのかin vitroの解析では限界がある。マウスなどの実験動物は化合物の作用を個体で最初に検討するために、極めて有益なモデルである。そこで、分子プロファイリング支援班では、マウスを使用した化合物のfirst-in-mouse解析を支援する。

When you have compounds discovered and developed from in vitro experiments using proteins and cells, such in vitro analyses can hardly predict how those compounds exert their effects in living organisms. Experimental animals such as mice are extremely useful models for first examining the action of compounds in individuals. Therefore, we support first-in-mouse analysis of such compounds using mice.

Method and evaluation


Compounds are administered to laboratory mice (ICR, etc.) orally (po), intravenously (iv), intraperitoneally (ip), etc. by a route according to the purpose of analysis and the physical properties of the compounds. Changes in individual life or death, behavior, physical condition, body weight, etc. are followed up for 2 weeks. Then, the mice are dissected and checked for abnormalities and weight of organs. Regarding cooperation with “Support for Pathologic Analysis”, we will discuss the support contents in advance and consider it.